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37
Cat. No. | Product Name | Target | Signaling Pathways |
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T33516 |
Msh (5-10), cyclic
Cyclic H-asp-his-phe-arg-trp-lys-NH2 |
||
Msh (5-10), cyclic, as a synthetic peptide, can conjugate with fatty acids for enhanced potency. | |||
T82880 |
Biotin-H10
|
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Biotin-H10,作为一种特异性抑制剂,针对前梯度蛋白2 (AGR2),其KD值为6.4 nM。此化合物能有效抑制癌细胞活力。 | |||
T60280 |
3,6-Diamino-9(10H)-acridone
|
||
3,6-Diamino-9(10H)-acridone 是拓扑异构酶的抑制剂。 | |||
T125216 |
7,8,9-Trimethoxy-10H-1,3-dioxolo[4,5-b]xanthen-10-one
|
||
7,8,9-Trimethoxy-10H-1,3-dioxolo[4,5-b]xanthen-10-one 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T125216。 | |||
T126216 |
1α,7α,10αH-Guaia-4,11-dien-3-one
|
||
1α,7α,10αH-Guaia-4,11-dien-3-one 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T126216。 | |||
T66988 |
10-Bromo-5H-dibenzo[b,f]azepine-5-carboxamide
|
||
10-Bromo-5H-dibenzo[b,f]azepine-5-carboxamide 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T66988,CAS号为 59690-97-0。 | |||
T66298 | (8S,9S,10R,14S)-13-Ethyl-11-methylene-2,3,7,8,9,10,11,12,13,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17(6H)-one | ||
(8S,9S,10R,14S)-13-Ethyl-11-methylene-2,3,7,8,9,10,11,12,13,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17(6H)-one 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T66298,CAS号为 54024-21-4。 | |||
T67021 |
(6bR,10aS)-Ethyl 3-methyl-2,3,6b,7,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline-8(9H)-carboxylate
|
||
(6bR,10aS)-Ethyl 3-methyl-2,3,6b,7,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline-8(9H)-carboxylate 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T67021,CAS号为 313369-26-5。 | |||
T67022 | (6bR,10aS)-Ethyl 3-methyl-2-oxo-2,3,6b,7,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline-8(9H)-carboxylate | ||
(6bR,10aS)-Ethyl 3-methyl-2-oxo-2,3,6b,7,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline-8(9H)-carboxylate 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T67022,CAS号为 313369-25-4。 | |||
T65734 |
2-Methyl-10H-benzo[b]thieno[2,3-e][1,4]diazepin-4-amine hydrochloride
|
||
2-Methyl-10H-benzo[b]thieno[2,3-e][1,4]diazepin-4-amine hydrochloride 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T65734,CAS号为 138564-60-0。 | |||
T67023 | (6bR,10aS)-3-Methyl-2,3,6b,7,8,9,10,10a-octahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline | ||
(6bR,10aS)-3-Methyl-2,3,6b,7,8,9,10,10a-octahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T67023,CAS号为 313368-85-3。 | |||
T64502 | (S)-Decarboxyl ofloxacin | ||
(S)-Decarboxyl ofloxacin 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T64502。 | |||
T65404 | (2'R,7R,8R,10S,13S,14S)-Methyl 10,13-dimethyl-3,5'-dioxo-1,2,3,4',5',6,7,8,10,12,13,14,15,16-tetradecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-carboxylate | ||
(2'R,7R,8R,10S,13S,14S)-Methyl 10,13-dimethyl-3,5'-dioxo-1,2,3,4',5',6,7,8,10,12,13,14,15,16-tetradecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-carboxylate 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T65404,CAS号为 95716-70-4。 | |||
T64494 | 1-(Chloromethyl)-1-methyl-4-(2-methyl-10H-thieno[2,3-b][1,5]benzodiazepin-4-yl)-piperazinium chloride | ||
1-(Chloromethyl)-1-methyl-4-(2-methyl-10H-thieno[2,3-b][1,5]benzodiazepin-4-yl)-piperazinium chloride 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T64494。 | |||
T66301 | (3S,8R,9S,10R,13S,14S)-17-Iodo-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol | ||
(3S,8R,9S,10R,13S,14S)-17-Iodo-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T66301,CAS号为 32138-69-5。 | |||
T65075 |
(3S,8S,9S,10R,13R,14S,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl (Z)-octadec-9-en-1-yl carbonate
|
||
(3S,8S,9S,10R,13R,14S,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl (Z)-octadec-9-en-1-yl carbonate 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T65075,CAS号为 17110-51-9。 | |||
T64564 |
1-(9H-Fluoren-9-yl)-3-oxo-2,7,10,13,16,19,22,25,28,31,34,37-dodecaoxa-4-azatetracontan-40-oic acid
|
||
1-(9H-Fluoren-9-yl)-3-oxo-2,7,10,13,16,19,22,25,28,31,34,37-dodecaoxa-4-azatetracontan-40-oic acid 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T64564。 | |||
T64669 |
(R)-4-((3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-Trihydroxy-7,10,13-trimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid
|
||
(R)-4-((3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-Trihydroxy-7,10,13-trimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T64669。 | |||
T64990 |
(2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-10,13-Dimethyl-2,16-di(piperidin-1-yl)hexadecahydro-1H-cyclopenta[a]phenanthrene-3,17-diol
|
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(2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-10,13-Dimethyl-2,16-di(piperidin-1-yl)hexadecahydro-1H-cyclopenta[a]phenanthrene-3,17-diol 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T64990,CAS号为 13522-16-2。 | |||
T64635 | 8-Phenyl-2,6-diethyl-BODIPY 505/515 | ||
2,8-Diethyl-5,5-difluoro-1,3,7,9-tetramethyl-10-phenyl-5H-4l4,5l4-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinine 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T64635。 | |||
T66656 |
(R)-Methyl 4-((3R,5S,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-7-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate
|
||
(R)-Methyl 4-((3R,5S,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-7-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T66656,CAS号为 10538-59-7。 | |||
T66748 | (R)-Methyl 4-((3R,5R,6S,8S,9S,10R,13R,14S,17R)-3,6-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate | ||
(R)-Methyl 4-((3R,5R,6S,8S,9S,10R,13R,14S,17R)-3,6-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T66748,CAS号为 2868-48-6。 | |||
T66990 | (R)-Benzyl 4-((3R,5R,8S,9S,10R,13R,14S,17R,E)-6-ethylidene-3-hydroxy-10,13-dimethyl-7-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate | ||
(R)-Benzyl 4-((3R,5R,8S,9S,10R,13R,14S,17R,E)-6-ethylidene-3-hydroxy-10,13-dimethyl-7-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T66990,CAS号为 1352328-66-5。 | |||
T66136 | (R)-Methyl 4-((3R,5S,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-7-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate | ||
(R)-Methyl 4-((3R,5S,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-7-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T66136,CAS号为 10538-65-5。 | |||
T66741 |
(R)-4-((3R,5R,8S,9S,10R,13R,14S,17R,E)-6-Ethylidene-3-hydroxy-10,13-dimethyl-7-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid
|
||
(R)-4-((3R,5R,8S,9S,10R,13R,14S,17R,E)-6-Ethylidene-3-hydroxy-10,13-dimethyl-7-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T66741,CAS号为 1516887-33-4。 | |||
T64448 | 11-Keto budesonide | ||
11-Keto budesonide 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T64448。 | |||
T65298 |
(4aR,4bS,6aS,7S,9aS,9bS,11aR)-Methyl 4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxylate
|
||
(4aR,4bS,6aS,7S,9aS,9bS,11aR)-Methyl 4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxylate 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T65298。 | |||
T66996 | (4aR,4bS,6aS,7S,9aS,9bS,11aR)-4a,6a-Dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid | ||
(4aR,4bS,6aS,7S,9aS,9bS,11aR)-4a,6a-Dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T66996,CAS号为 104239-97-6。 | |||
T21493 |
Cyclosporin H
|
Others | Others |
Cyclosporin H 是一种 FPR-1(甲酰肽受体 1) 的选择性强效抑制剂。它缺乏 Cyclosporin A 具有的免疫抑制活性。它是一种病毒转导增强剂,可使人脐带血来源的造血干细胞和祖细胞中慢病毒转导增强 10 倍。它与雷帕霉素或前列腺素 E2 联合使用时表现出累加效应。 | |||
T7587 |
Tenapanor
RDX-5791,RDX 5791,AZD 1722,Tenapanor free base,RDX5791,AZD-1722,AZD1722 |
Sodium Channel | Membrane transporter/Ion channel |
Tenapanor (RDX 5791) 是钠氢离子交换NHE3的有效抑制剂, 对人和大鼠NHE3的IC50分别是5和10 nM。 | |||
T0153 |
Oltipraz
吡噻硫酮,NSC 347901,RP 35972 |
HIF/HIF Prolyl-Hydroxylase; HIV Protease; Reverse Transcriptase; Nrf2; HIF | Angiogenesis; Chromatin/Epigenetic; Immunology/Inflammation; Metabolism; Microbiology/Virology; Proteases/Proteasome |
Oltipraz (RP 35972) 是一种 Nrf2的强效激活剂。它时间依赖性地抑制 HIF-1α激活,IC50为 10 μM,浓度 ≥ 10 μM 时完全消除 HIF-1α诱导。 | |||
T9009 |
ICA-105574
ICA,3-nitro-N-[4-phenoxyphenyl]-benzamide |
HER | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
ICA-105574 (ICA) 是 hERG 通道激活剂。它通过消除 hERG 通道的失活从而增强 hERG 通道活性。它可以把电流幅度急剧增加到原来的 10 倍以上,其EC50值为 0.5 +/- 0.1 μM,Hill 斜率 (n(H)) 为 3.3 +/- 0.2。 | |||
T14943 |
CGP60474
|
VEGFR; CDK; PKC | Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors |
CGP60474 是一种高效的抗内毒素药物,抑制细胞周期蛋白依赖激酶(CDK) ,抑制 CDK1/B、CDK2/E、CDK2/a、CDK4/D、CDK5/p25、CDK7/H 和 CDK9/T 的IC50分别为 26、3、4、216、10、200 和 13 nM。它是选择性和 ATP 竞争性PKC 抑制剂。 | |||
T16389 | Omidenepag | Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation |
Omidenepag is a pharmacologically active form of Omidenepag Isopropyl and is a selective, non-prostanoid EP2 receptor agonist (EC50: 1.1 nM). Omidenepag displays binding affinities (IC50: 10 nM for h-EP2). | |||
T74380 |
XY-06-007
|
||
XY-06-007 是一种有效的选择性 B&H-PROTACBRD4BD1L94V 降解剂。XY-06-007 对BRD4BD1L94V 的DC50, 6 h 为 10 nM。XY-06-007 且具有适合的体内药代动力学特征。 | |||
T15353 |
FTI-2153
|
Others | Others |
FTI-2153 is a potent and highly selective farnesyltransferase (FTase) inhibitor (IC50: 1.4 nM). FTI-2153 is >3000-fold more potent at blocking H-Ras (IC50, 10 nM) than Rap1A processing. | |||
T61032 | Carbonic anhydrase inhibitor 10 | ||
Carbonic anhydrase inhibitor 10 可用于研究癌症,它对 MCF-7 癌细胞表现出抗增殖活性, IC50值为 11.9 μM。Carbonic anhydrase inhibitor 10 是 hCA IX 的有效抑制剂,Ki 值为 6.2 nM。 | |||
T13845 |
PROTAC PARP1 degrader
|
Others | Others |
PROTAC PARP1 degrader is a degrader of PARP1 based on the PROTAC technology. PROTAC PARP1 degrader at 10 μM at 24 h inhibits MDA-MB-231 cell line (IC50 of 6.12 μM). | |||
T70642 |
Lanopepden camsylate
|
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Lanopepden, also known as GSK-1322322 or GSK-322, is a potent and selective peptide deformylase inhibitor with good in vitro activity against bacteria associated with community-acquired pneumonia and skin infections. GSK1322322 had bactericidal activity against S. pneumoniae, H. influenzae, S. pyogenes, and S. aureus, demonstrating a ≥ 3-log(10) decrease in the number of CFU/ml at 4× MIC within 24 h in 29 of the 33 strains tested. GSK1322322 represents a valuable alternative therapy for the trea... | |||
T69589 |
PX-316
|
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PX-316 is a AKT inhibior. PX-316, when administered intraperitoneally to mice at 150 mg/kg, inhibits Akt activation in HT-29 human tumor xenografts up to 78% at 10 h with recovery to 34% at 48 h. PX-316 has antitumor activity against early human MCF-7 breast cancer and HT-29 colon cancer xenografts in mice. PX-316 formulated in 20% hydroxypropyl-beta-cyclodextrin for intravenous administration is well tolerated in mice and rats with no hemolysis and no hematological toxicity. Thus, PX-316 is the... | |||
T68765 |
Spirorenone
|
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Spirorenone is an androstadienone derivative as a highly effective aldosterone antagonist. Spirorenone is 8.6 times as potent as spironolactone, but showed a lower affinity for the mineralocorticoid receptors. In phase I clinical trials Spirorenone was absorbed with a half-life of 20-30 min, achieving maximum concentrations of about 100 ng/ml (10 mg) and 260 ng/ml (40 mg) after 1-2 h. Disposition of the parent drug was biphasic with half-lives of 50-60 min (distribution) and 5-6 h (elimination).... | |||
T36784 |
Filipin II
|
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Filipin II is a polyene and an active component of the polyene antibiotic filipin complex . [1] It has broad-spectrum antifungal activity, reducing growth of various fungi, including B. dermatitidis, C. neoformans, and H. capsulatum (MICs = 1-10 μg/ml). Filipin II inhibits ADP-stimulated respiration in rat liver mitochondria when used at a concentration of 3.5 mg/ml. [2] It also induces hemolysis of liposomes in a cholesterol-independent manner (IC50 = 0.5 μg/ml).[3] | |||
T38160 |
STING Agonist 1a
|
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STING agonist 1a is an agonist of stimulator of interferon genes (STING).1It induces expression of an IRF-inducible SEAP reporter gene in a cell-based assay (EC50= 16.77 μM). STING agonist 1a (12.5-100 μM) induces expression of IFN-β, IL-6, and chemokine (C-X-C motif) ligand 10 (CXCL10) in THP-1 cells, an effect that can be reversed by STING knockout or the STING inhibitor H-151 . 1.Hou, H., Yang, R., Liu, X., et al.Discovery of triazoloquinoxaline as novel STING agonists via structure-based vir... | |||
T71908 |
NU1085
|
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NU1085 is a potent poly(ADP-ribose) polymerase (PARP) inhibitors have been developed that potentiate the cytotoxicity of ionizing radiation and anticancer drugs. The biological effects of NU1085 [Ki = 6 nM], in combination with temozolomide (TM) or topotecan (TP) have been studied in 12 human tumor cell lines (lung, colon, ovary, and breast cancer). Cells were treated with increasing concentrations of TM or TP +/- NU1085 (10 microM) for 72 h. | |||
T36254 | dTAGV-1 hydrochloride | ||
Hydrochloride salt of dTAGV-1. Suitable for use in vivo. Following ip administration of 10 mg/kg in mice: T = 4.43 h; Cmax = 2123 ng mL-1; AUCinf = 18517 hr*ng mL-1 and CL = 9.05 mL min-1 kg-1 Negative control dTAGV-1-NEG also available. Important: It is recommended that DMSO stock solutions of this compound are made and used on the same day and are not subjected to freeze/thaw. | |||
T38350 |
TAS 205
|
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TAS 205 is an inhibitor of hematopoietic prostaglandin D synthase (H-PGDS; IC50= 55.8 nM).1It is selective for H-PGDS over lipocalin-type PGDS (L-PGDS) at 100 μM, as well as over enzyme and receptor panels at 10 μM. TAS 205 inhibits production of prostaglandin D2induced by A23187 in KU812 human and RBL-2H3 rat basophils with IC50values of 78.3 and 181.3 nM, respectively. It inhibits ovalbumin-induced nasal lavage fluid eosinophil infiltration and late-phase nasal obstruction in an ovalbumin-sens... | |||
T74258 | HL-8 | ||
HL-8 是一种靶向PI3K 激酶的PROTAC 分子。HL-8 在10 μM 浓度下 8 h 内对PI3K 激酶具有显着且完全的降解作用。HL-8 具有研究癌症疾病的潜力。 | |||
T65396 |
Piperazine 2HCl
|
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Piperazine (2HCl) is gamma-aminobutyric acid (GABA) agonists and its major effects appear to be on the central nervous system. Piperazine was the anthelmintic with the greatest number of reports of toxicoses and suspected toxicoses in cats. Piperazine neurotoxicity in cats and dogs usually was manifested by muscle tremors, ataxia, and/or behavioral disturbances within 24 hours after estimated daily dose(s) between 20 and 110 mg/kg[1]. For di-substituted derivatives, ciprofloxacin was selected an... | |||
T33699 |
NLCQ-1 HCl
NLCQ1,NLCQ-1, NLCQ 1,NSC 709257 |
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NLCQ-1 is a novel weak DNA-intercalative bioreductive compound. NLCQ-1 exhibited a C50 of 44 microM. NLCQ-1 demonstrated significant hypoxic selectivity in several rodent (V79, EMT6, SCCVII) or human (A549, OVCAR-3) tumor cell lines. Its potency as a hypo | |||
T35459 |
Glycyl H-1152 hydrochloride
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Two Rho-associated kinases (ROCK), ROCK-I and ROCK-II, act downstream of the G protein Rho to regulate cytoskeletal stability. The ROCKs play important roles in diverse cellular functions including cell adhesion and proliferation, smooth muscle contraction, and stem cell renewal. Glycyl-H-1152 is a selective and potent ROCK inhibitor (IC50 = 11.8 nM for ROCK-II). It is a glycylated isoquinoline compound derived from the therapeutically-important ROCK inhibitor HA-1077 (Fasudil) and exhibits bett... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T83558 |
(3S,4aS,10aS)-3-(Acetyloxy)-2,3,4,4a,10,10a-hexahydro-6-hydroxy-1,1,4a-trimethyl-7-(1-methylethyl)-9(1H)-phenanthrenone
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(3S,4aS,10aS)-3-(Acetyloxy)-2,3,4,4a,10,10a-hexahydro-6-hydroxy-1,1,4a-trimethyl-7-(1-methylethyl)-9(1H)-phenanthrenone(化合物3)是从丹参(Salvia miltiorrhiza)根提取的棕榈酸盐。该化合物展现出抗癌活性,对于不同的人类癌症细胞系具有显著的抑制效果,其DC50值分别为:HeLa细胞系25.5 μg/mL、HepG2细胞系37.5 μg/mL以及OVCAR-3细胞系30.2 μg/mL。 | |||
TN2413 |
Diacetylpiptocarphol
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Others | Others |
Diacetylpiptocarphol has antiplasmodial activity | |||
TN3049 |
4-Methoxycinnamyl alcohol
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Others | Others |
4-Methoxycinnamyl alcohol 对MCF-7、HeLa 和DU145癌症细胞系显示出毒性,IC50值分别为14.24、7.82和22.10μg/mL。4-methoxycinnamyl alcohol 是从Foeniculum vulgare 中分离出来的。4-Methoxycinnamyl alcohol 没有显示出凋亡作用,却在10μg/mL DNA 碎片研究显示48小时后发生了坏死。 | |||
T36226 |
Beauveriolide I
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Beauveriolide I is a cyclodepsipeptide that has been found inBeauveriaand an inhibitor of lipid droplet formation.1It inhibits lipid droplet formation when used at concentrations of 3 and 10 μM, as well as inhibits cholesterol synthesis (IC50= 0.78 μM), in primary mouse peritoneal macrophages.1,2Beauveriolide I also inhibits acyl-coenzyme A:cholesterol acyltransferase (ACAT) activity in mouse macrophage membranes (IC50= 6 μM).2 1.Namatame, I., Tomoda, H., Si, S., et al.Beauveriolides, specific i... | |||
T37609 |
(rel)-Asperparaline A
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Aspergillimide is a fungal metabolite originally isolated from A. japonicus.1 It reduces nicotinic acetylcholine receptor (nAChR) peak and slowly-desensitizing amplitudes induced by acetylcholine in silkworm (B. mori) larval neurons (IC50s = 20.2 and 39.6 nM, respectively) but has no effect on chicken α3β4-, α4β2-, and α7-containing nAChRs.2 Dietary administration of aspergillimide A (10 μg/g of diet) induces paralysis in silkworm fourth instar larvae.1 Aspergillimide A (10 and 20 mg/kg) reduces... | |||
T36227 |
Beauveriolide III
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Beauveriolide III is a cyclodepsipeptide that has been found inBeauveriaand an inhibitor of lipid droplet formation.1It inhibits lipid droplet formation when used at concentrations of 3 and 10 μM, as well as inhibits cholesterol synthesis (IC50= 0.41 μM), in primary mouse peritoneal macrophages.1,2Beauveriolide III also inhibits acyl-coenzyme A:cholesterol acyltransferase (ACAT) activity in mouse macrophage membranes (IC50= 5.5 μM).2Beauveriolide III (25 and 50 mg/kg) reduces the size of aortic ... | |||
T36448 |
(E)-Ajoene
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(E)-Ajoene is a disulfide that has been found inA. sativumand has diverse biological activities.1,2,3,4It is active against Gram-positive and Gram-negative bacteria (MICs = 10-250 and 150->500 μg/ml, respectively) and fungi (MICs = 15-50 μg/ml).1(E)-Ajoene inhibits proliferation of a variety of cancer cells, including MDA-MB-231 breast, HeLa cervical, and WHCO1 esophageal cancer cells (IC50s = 18.6, 61, and 39.2 μM, respectively).2It also inhibits human glutathione reductase andT. cruzitrypanoth... |
Cat. No. | Product Name | Species | Expression System |
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TMPY-02580 |
Histone H1 Protein, Human, Recombinant (His)
HSP60,HSP65,CPN60,H1 his... |
Human | E. coli |
H1 histone family, member 0 (H1F0) is a member of the H1 histone family of nuclear proteins which are a component of chromatin in eukaryotic cells. It's involved in maintaining the structure of chromatin by packing the "beads on a string" sub-structure into a high order structure. The lysine-rich H1 histone family in mammals includes eleven members. In higher eukaryotes, all H1 variants have the same general structure, consisting of a central conserved globular domain and less conserved N-termin... | |||
TMPY-00957 |
Influenza A H3N2 (A/Brisbane/10/2007) Hemagglutinin/HA Protein (His)
Harvey rat sarcoma viral oncogene homolog |
H3N2 | HEK293 Cells |
Influenza A H3N2 (A/Brisbane/10/2007) Hemagglutinin/HA Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 59 kDa and the accession number is A8W8K8. | |||
TMPY-02662 |
Influenza A H10N8 (A/Jiangxi-Donghu/346/2013) Hemagglutinin/HA Protein (His)
Harvey rat sarcoma viral oncogene homolog |
H10N8 | Baculovirus Insect Cells |
Influenza A H10N8 (A/Jiangxi-Donghu/346/2013) Hemagglutinin/HA Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 57.9 kDa. | |||
TMPY-00416 |
Influenza A H10N8 (A/Jiangxi-Donghu/346/2013) Hemagglutinin/HA0 Protein
Harvey rat sarcoma viral oncogene homolog |
H10N8 | Baculovirus Insect Cells |
Influenza A H10N8 (A/Jiangxi-Donghu/346/2013) Hemagglutinin/HA0 Protein is expressed in Baculovirus insect cells. The predicted molecular weight is 60.6 kDa. | |||
TMPY-01198 |
Influenza A H3N2 (A/Brisbane/10/2007) Hemagglutinin Protein (His)
Harvey rat sarcoma viral oncogene homolog |
H3N2 | HEK293 Cells |
Influenza A H3N2 (A/Brisbane/10/2007) Hemagglutinin Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38 kDa and the accession number is A8W8K8. | |||
TMPY-00024 |
Influenza A H3N2 (A/Moscow/10/1999) Hemagglutinin/HA Protein (His)
Harvey rat sarcoma viral oncogene homolog |
H3N2 | Baculovirus Insect Cells |
Influenza A H3N2 (A/Moscow/10/1999) Hemagglutinin/HA Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 59.3 kDa and the accession number is Q1NZ37. | |||
TMPY-01530 |
Influenza A H10N3 (A/duck/Hong Kong/786/1979) Hemagglutinin/HA Protein (His)
Harvey rat sarcoma viral oncogene homolog |
H10N3 | HEK293 Cells |
Influenza A H10N3 (A/duck/Hong Kong/786/1979) Hemagglutinin/HA Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.8 kDa and the accession number is A2V811. | |||
TMPY-00110 |
Influenza A H10N9 (A/duck/Hong Kong/562/1979) Hemagglutinin/HA Protein (His)
Harvey rat sarcoma viral oncogene homolog |
H10N9 | Baculovirus Insect Cells |
Influenza A H10N9 (A/duck/Hong Kong/562/1979) Hemagglutinin/HA Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 57.8 kDa and the accession number is Q0A4B5. | |||
TMPY-04306 |
Influenza A H3N2 (A/Moscow/10/1999) Hemagglutinin/HA1 Protein (His)
Harvey rat sarcoma viral oncogene homolog |
H3N2 | HEK293 Cells |
Influenza A H3N2 (A/Moscow/10/1999) Hemagglutinin/HA1 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38 kDa and the accession number is Q1NZ37. | |||
TMPY-00204 |
Influenza A H7N9 (A/Zhejiang/DTID-ZJU10/2013) Hemagglutinin/HA Protein (His)
Harvey rat sarcoma viral oncogene homolog |
H7N9 | Baculovirus Insect Cells |
Influenza A H7N9 (A/Zhejiang/DTID-ZJU10/2013) Hemagglutinin/HA Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 57.6 kDa and the accession number is U6A0I2. | |||
TMPY-00019 |
Influenza A H10N8 (A/duck/Guangdong/E1/2012) Neuraminidase/NA Protein (His)
NA Protein,Neuraminidase |
H10N8 | Baculovirus Insect Cells |
Influenza A H10N8 (A/duck/Guangdong/E1/2012) Neuraminidase/NA Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 50.2 kDa and the accession number is I6PU08. | |||
TMPY-02416 |
Influenza A H10N3 (A/mallard/Minnesota/Sg-00194/2007) Hemagglutinin/HA Protein (His)
Harvey rat sarcoma viral oncogene homolog |
H10N3 | Baculovirus Insect Cells |
Influenza A H10N3 (A/mallard/Minnesota/Sg-00194/2007) Hemagglutinin/HA Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 57.9 kDa and the accession number is C6Y4Y2. | |||
TMPY-03803 |
Influenza A H5N1 (A/barnswallow/HongKong/D10-1161/2010) Hemagglutinin/HA Protein (His)
Harvey rat sarcoma viral oncogene homolog |
H5N1 | Baculovirus Insect Cells |
Influenza A H5N1 (A/barnswallow/HongKong/D10-1161/2010) Hemagglutinin/HA Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 60.2 kDa and the accession number is L7S370. | |||
TMPY-02655 |
Influenza A H10N9 (A/duck/Hong Kong/562/1979) Hemagglutinin/HA1 Protein (His)
Harvey rat sarcoma viral oncogene homolog |
H10N9 | HEK293 Cells |
Influenza A H10N9 (A/duck/Hong Kong/562/1979) Hemagglutinin/HA1 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.7 kDa and the accession number is Q0A4B5. | |||
TMPY-04326 |
Influenza A H10N8 (A/Jiangxi-Donghu/346/2013) Hemagglutinin/HA1 Protein (His)
Harvey rat sarcoma viral oncogene homolog |
H10N8 | HEK293 Cells |
Influenza A H10N8 (A/Jiangxi-Donghu/346/2013) Hemagglutinin/HA1 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.9 kDa. | |||
TMPY-01499 |
Influenza A H10N3 (A/duck/Hong Kong/786/1979) Hemagglutinin/HA1 Protein (His)
Harvey rat sarcoma viral oncogene homolog |
H10N3 | HEK293 Cells |
Influenza A H10N3 (A/duck/Hong Kong/786/1979) Hemagglutinin/HA1 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.7 kDa and the accession number is A2V811. | |||
TMPY-00293 |
Influenza A H9N2 (A/Guinea fowl/Hong Kong/WF10/99) Hemagglutinin/HA Protein (His)
Harvey rat sarcoma viral oncogene homolog |
H9N2 | Baculovirus Insect Cells |
Influenza A H9N2 (A/Guinea fowl/Hong Kong/WF10/99) Hemagglutinin/HA Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 58.2 kDa and the accession number is Q80KD9. | |||
TMPY-04652 |
Influenza A H17N10 (A/little yellow-shouldered bat/Guatemala/164/2009) Hemagglutinin/HA Protein (His)
Harvey rat sarcoma viral oncogene homolog |
H17N10 | Baculovirus Insect Cells |
Influenza A H17N10 (A/little yellow-shouldered bat/Guatemala/164/2009) Hemagglutinin/HA Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 59 kDa and the accession number is H6QM73. | |||
TMPY-00015 |
Influenza A H10N8 (A/duck/Guangdong/E1/2012) Hemagglutinin/HA1 Protein (His)
Harvey rat sarcoma viral oncogene homolog |
H10N8 | HEK293 Cells |
Influenza A H10N8 (A/duck/Guangdong/E1/2012) Hemagglutinin/HA1 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37 kDa and the accession number is I6PXD4. | |||
TMPY-00017 |
Influenza A H10N3 (A/duck/Hunan/S11205/2012) Hemagglutinin/HA1 Protein (His)
Harvey rat sarcoma viral oncogene homolog |
H10N3 | HEK293 Cells |
Influenza A H10N3 (A/duck/Hunan/S11205/2012) Hemagglutinin/HA1 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.8 kDa and the accession number is S0AUA5. | |||
TMPY-04186 |
Influenza A H10N3 (A/mallard/Minnesota/Sg-00194/2007) Hemagglutinin/HA1 Protein (His)
Harvey rat sarcoma viral oncogene homolog |
H10N3 | HEK293 Cells |
Influenza A H10N3 (A/mallard/Minnesota/Sg-00194/2007) Hemagglutinin/HA1 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.7 kDa and the accession number is C6Y4Y2. | |||
TMPY-04873 |
Influenza A H10N7 (A/blue-winged teal/Louisiana/Sg-00073/2007) Hemagglutinin/HA Protein (His)
Harvey rat sarcoma viral oncogene homolog |
H10N7 | Baculovirus Insect Cells |
Influenza A H10N7 (A/blue-winged teal/Louisiana/Sg-00073/2007) Hemagglutinin/HA Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 58 kDa and the accession number is D7EET9. | |||
TMPY-04234 |
Influenza A H17N10 (A/little yellow-shouldered bat/Guatemala/164/2009) Hemagglutinin/HA1 Protein (His)
Harvey rat sarcoma viral oncogene homolog |
H17N10 | HEK293 Cells |
Influenza A H17N10 (A/little yellow-shouldered bat/Guatemala/164/2009) Hemagglutinin/HA1 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37.7 kDa and the accession number is H6QM73. | |||
TMPY-01626 |
Influenza A H9N2 (A/Guinea fowl/Hong Kong/WF10/99) Hemagglutinin/HA1 Protein (His)
Harvey rat sarcoma viral oncogene homolog |
H9N2 | HEK293 Cells |
Influenza A H9N2 (A/Guinea fowl/Hong Kong/WF10/99) Hemagglutinin/HA1 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 37 kDa and the accession number is Q80KD9. | |||
TMPY-04179 |
Influenza A H5N1 (A/barn swallow/Hong Kong/D10-1161/2010) Hemagglutinin/HA1 Protein (His)
Harvey rat sarcoma viral oncogene homolog |
H5N1 | HEK293 Cells |
Influenza A H5N1 (A/barn swallow/Hong Kong/D10-1161/2010) Hemagglutinin/HA1 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38.2 kDa and the accession number is L7S370. | |||
TMPY-00556 |
Influenza A H5N1 (A/barnswallow/HongKong/D10-1161/2010) Hemagglutinin Protein (HA1+HA2, His)
Harvey rat sarcoma viral oncogene homolog |
H5N1 | Baculovirus Insect Cells |
Influenza A H5N1 (A/barnswallow/HongKong/D10-1161/2010) Hemagglutinin Protein (HA1+HA2, His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 59.8 kDa and the accession number is L7S370. | |||
TMPY-04594 |
Influenza A H10N7 (A/blue-winged teal/Louisiana/Sg-00073/2007) Hemagglutinin/HA1 Protein (His)
Harvey rat sarcoma viral oncogene homolog |
H10N7 | HEK293 Cells |
Influenza A H10N7 (A/blue-winged teal/Louisiana/Sg-00073/2007) Hemagglutinin/HA1 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.7 kDa and the accession number is D7EET9. | |||
TMPH-00616 |
DNA-binding protein H-NS Protein, E. coli, Recombinant (His)
hns,DNA-binding protein H-NS,Protein B1,Pr... |
E. coli | E. coli |
A DNA-binding protein implicated in transcriptional repression (silencing). Also involved in bacterial chromosome organization and compaction. H-NS binds tightly to AT-rich dsDNA and inhibits transcription. Binds upstream and downstream of initiating RNA polymerase, trapping it in a loop and preventing transcription. Binds to hundreds of sites, approximately half its binding sites are in non-coding DNA, which only accounts for about 10% of the genome. Many of these loci were horizontally transfe... | |||
TMPY-01751 |
DR3/TNFRSF25 Protein, Human, Recombinant (hFc)
TRAMP,TR3,WSL-1,TNFRSF12,DR3,WSL-LR,tumor necrosis factor re... |
Human | HEK293 Cells |
DR3/TNFRSF25 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.9 kDa and the accession number is Q93038-10. | |||
TMPY-05760 |
DR3/TNFRSF25 Protein, Human, Recombinant (hFc), Biotinylated
TRAMP,tumor necrosis factor receptor superfamily, member 25,... |
Human | HEK293 Cells |
DR3/TNFRSF25 Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.9 kDa and the accession number is Q93038-10. | |||
TMPY-00961 |
ADAM15 Protein, Human, Recombinant (His)
MDC15,ADAM metallopeptidase domain 15 |
Human | HEK293 Cells |
ADAM15 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 54 kDa and the accession number is Q13444-10. | |||
TMPY-02300 |
BIN1 Protein, Human, Recombinant (His)
AMPHL,bridging integrator 1,AMPH2,SH |
Human | E. coli |
Amphiphysin 2, also named bridging integrator-1 (BIN1) or SH3P9, Amphiphysin2/BIN1 is a crescent-shaped N-BAR protein playing a key role in forming deeply invaginated tubes in muscle T-tubules, has been recently implicated in rare and common diseases affecting different tissues and physiological functions. BIN1 downregulation is linked to cancer progression and also correlates with ventricular cardiomyopathy and arrhythmia preceding heart failure. Increased BIN1 expression is linked to increased... | |||
TMPK-01413 |
H-2K (b) &B2M&OVA (SIINFEKL) Monomer Protein, Mouse, MHC (His & Avi)
H-2K,OVA,MHC,H2-K1 |
Mouse | HEK293 Cells |
Ovalbumin (OVA) has been historically a popular source of such antigens, since OVA can induce both humoral and cellular immune responses based on well-characterised peptide epitopes. The OVA257-264 octapeptide was one of the frst OVA epitopes to be characterised, it has an amino acid sequence SIINFEKL, which is recognised by cytotoxic T lymphocytes. SIINFEKL forms fbrillar assemblies similar to other peptide hydrogels. Te immunoactive properties of this peptide can therefore be related to its se... | |||
TMPK-01523 |
Chimeric HLA-A*02:01 (mα3) &B2M&WT-1 (RMFPNAPYL) Monomer Protein, Human&Mouse, MHC (His & Avi)
WAGR,WT33,AWT1,GUD,RMF,WT1,WIT-2,MHC,NPHS4... |
Human & Mouse | HEK293 Cells |
The WT1 protein plays a role in cell growth, the process by which cells mature to perform specific functions (differentiation), and the self-destruction of cells (apoptosis). WT1 is differentially expressed in serous, endometrioid, clear cell, and mucinous carcinomas of the peritoneum, fallopian tube, ovary, and endometrium.The Human HLA-A*0201 WT-1 (RMFPNAPYL) complex Protein is a complex of HLA-A*0201 of the MHC Class I, B2M and RMFPNAPYL peptide of the WT-1. | |||
TMPK-01534 |
Chimeric HLA-A*02:01 (mα3) &B2M&LMP2 (CLGGLLTMV) Monomer Protein, Human&Mouse, MHC (His & Avi)
RING12,PSMB9,Proteasome chain 7,RMF,LMP-2,LMP2,M |
Human & Mouse | HEK293 Cells |
The immunoproteasome, having been linked to neurodegenerative diseases and hematological cancers, has been shown to play an important role in MHC class I antigen presentation. The development of molecular probes that selectively inhibit the major catalytic subunit, LMP2, of the immunoproteasome,LMP2-rich cancer cells compared to LMP2-deficient cancer cells are more sensitive to growth inhibition by the LMP2-specific inhibitor, implicating an important role of LMP2 in regulating cell growth of ma... | |||
TMPK-01522 |
Chimeric HLA-A*02:01 (mα3) &B2M&WT-1 (RMFPNAPYL) Tetramer Protein, Human&Mouse, MHC (His & Avi)
RMF,WT33,WIT-2,MHC,WAGR,AWT1,GUD,WT1,NPHS4... |
Human & Mouse | HEK293 Cells |
The WT1 protein plays a role in cell growth, the process by which cells mature to perform specific functions (differentiation), and the self-destruction of cells (apoptosis). WT1 is differentially expressed in serous, endometrioid, clear cell, and mucinous carcinomas of the peritoneum, fallopian tube, ovary, and endometrium.The Human HLA-A*0201 WT-1 (RMFPNAPYL) complex Protein is a complex of HLA-A*0201 of the MHC Class I, B2M and RMFPNAPYL peptide of the WT-1. | |||
TMPK-01535 |
Chimeric HLA-A*02:01 (mα3) &B2M&LMP2 (CLGGLLTMV) Tetramer Protein, Human&Mouse, MHC (His & Avi)
Macropain chain 7,LMP2,Proteasome chain 7,... |
Human & Mouse | HEK293 Cells |
The immunoproteasome, having been linked to neurodegenerative diseases and hematological cancers, has been shown to play an important role in MHC class I antigen presentation. The development of molecular probes that selectively inhibit the major catalytic subunit, LMP2, of the immunoproteasome,LMP2-rich cancer cells compared to LMP2-deficient cancer cells are more sensitive to growth inhibition by the LMP2-specific inhibitor, implicating an important role of LMP2 in regulating cell growth of ma... |